Genetic differences in caffeine metabolism may explain the Jekyll and Hyde effects of coffee.

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This is one of the rate instances where “personalized nutrition” isn’t just some marketing catch-phrase. Soy is another one, but in that case it’s just about who benefits the most. See: How to Convert Into an Equol Producer (

For more on coffee, see:
• Coffee and Artery Function (
• Does Coffee Affect Cholesterol? (
• Does Adding Milk Block the Benefits of Coffee? (
• Which Coffee Is Healthier: Light vs. Dark Roast (
• Does Low Acid Coffee Cause Less Acid Reflux? (

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Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution!
-Michael Greger, MD FACLM

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